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Article

Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins.

Nature structural & molecular biology - 5 Feb 2012

Chen Mo, David Charles J, Manley James L

Abstract excerpt

Expression of the mammalian pyruvate kinase M (PKM) gene provides an important example of mutually exclusive splicing. We showed previously that the hnRNP proteins A1, A2 and PTB have a crucial role in this process. Here we provide evidence that concentration-dependent interactions involving a network of these proteins are sufficient to determine the outcome of PKM splicing. At high concentrations, such as those...

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Identifiers

PMID: 22307054
DOI: 10.1038/nsmb.2219
PMCID: PMC3698866

Genes

PKM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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