Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dose-Dependent Regulation of Alternative Splicing by MBNL Proteins Reveals Biomarkers for Myotonic Dystrophy

28 Sept 2016

Abstract excerpt

Alternative splicing is a regulated process that results in expression of specific mRNA and protein isoforms. Alternative splicing factors determine the relative abundance of each isoform. Here we focus on MBNL1, a splicing factor misregulated in the disease myotonic dystrophy. By altering the concentration of MBNL1 in cells across a broad dynamic range, we show that different splicing events require different...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy and Myosin Studies
Share to Genetic Neurodegenerative Diseases
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27681373
DOI: 10.1371/journal.pgen.1006316

Provenance

PubMed metadata and Literature Corpus relationships.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dose-Dependent Regulation of Alternative Splicing by MBNL Proteins Reveals Biomarkers for Myotonic DystrophyPMID 27681373Read ↗

RNA splicing is responsive to MBNL1 dose.Semantic proximity Read ↗

Co-opting MBNL-dependent alternative splicing cassette exons to control gene therapy in myotonic dystrophySemantic proximity Read ↗

Autoregulated Splicing of muscleblind-like 1 (MBNL1) Pre-mRNASemantic proximity Read ↗

Characterisation of <i>DMPK</i> and MBNL1 expression in cell models of Myotonic Dystrophy: A platform for drug screeningSemantic proximity Read ↗

(CTG)n repeat-mediated dysregulation of MBNL1 and MBNL2 expression during myogenesis in DM1 occurs already at the myoblast stageSemantic proximity Read ↗

Splicing biomarkers of disease severity in myotonic dystrophySemantic proximity Read ↗

A comprehensive atlas of fetal splicing patterns in the brain of adult myotonic dystrophy type 1 patientsSemantic proximity Read ↗

Integrative proteogenomics for differential expression and splicing variation in a DM1 mouse modelSemantic proximity Read ↗

Expanded CUG Repeats Dysregulate RNA Splicing by Altering the Stoichiometry of the Muscleblind 1 ComplexSemantic proximity Read ↗

Interplay between DMD point mutations and splicing signals in Dystrophinopathy phenotypes.Semantic proximity Read ↗

Alternative splicing of myomesin 1 gene is aberrantly regulated in myotonic dystrophy type 1.Semantic proximity Read ↗

Alternative splicing regulation by Muscleblind proteins: from development to diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.