Article
Alternative splicing of the pyruvate kinase M gene in a minigene system.
European journal of biochemistry - 15 Jan 1996
Takenaka M, Yamada K, Lu T, Kang R, Tanaka T, Noguchi T
Abstract excerpt
The M1-type and M2-type isozymes of pyruvate kinase are produced from a single gene by mutually exclusive use of exons 9 and 10. Selection of exon 10 generates the M2 type, which occurs in most tissues, whereas the M1 type is expressed by use of exon 9 only in skeletal muscle, heart and brain. We investigated the mechanism by which exon 10, but not exon 9 is selected in M2-expressing cells by transfecting...
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