Article
Common variants at 11p13 are associated with susceptibility to tuberculosis.
Nature genetics - 5 Feb 2012
Thye Thorsten, Owusu-Dabo Ellis, Vannberg Fredrik O, van Crevel Reinout, Curtis James, Sahiratmadja Edhyana, Balabanova Yanina, Ehmen Christa, Muntau Birgit, Ruge Gerd, Sievertsen Jürgen, Gyapong John, Nikolayevskyy Vladyslav, Hill Philip C, Sirugo Giorgio, Drobniewski Francis, van de Vosse Esther, Newport Melanie, Alisjahbana Bachti, Nejentsev Sergey, Ottenhoff Tom H M, Hill Adrian V S, Horstmann Rolf D, Meyer Christian G
Abstract excerpt
After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.