Identification of a Novel Cis-Acting Regulator of HIV-1 Genome Packaging.

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) uptakes homo-dimerized viral RNA genome into its own particle. A cis-acting viral RNA segment responsible for this event, termed packaging signal (psi), is located at the 5'-end of the viral genome. Although the psi segment exhibits nucleotide variation in nature, its effects on the psi function largely remain unknown. Here we show that a psi sequence from an HIV-1...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Dimerization
• Share to Hydrogen Bonding
• Share to Molecular Dynamics Simulation