Article
Variability in transport and biotransformation of cytarabine is associated with its toxicity in peripheral blood mononuclear cells.
Pharmacogenomics - 1 Apr 2011
Parmar Sumit, Seeringer Angela, Denich Dina, Gärtner Franziska, Pitterle Kai, Syrovets Tatiana, Ohmle Barbara, Stingl Julia C
Abstract excerpt
AIM: To adopt an individualized approach to assess cytarabine (ara-C) hematotoxicity, we studied the relationship between pharmacogenetic variability in the cytidine deaminase gene (CDA) and ara-C toxicity in native peripheral blood mononuclear cells from 100 healthy volunteers. MATERIALS & METHODS: Peripheral blood mononuclear cells were incubated for 48 h with 3 µM ara-C, and cell viability was analyzed by flow...
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