Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The coronavirus endoribonuclease Nsp15 interacts with retinoblastoma tumor suppressor protein.

Journal of virology - 1 Apr 2012

Bhardwaj Kanchan, Liu Pinghua, Leibowitz Julian L, Kao C Cheng

Abstract excerpt

Coronaviruses encode an endoribonuclease, Nsp15, which has a poorly defined role in infection. Sequence analysis revealed a retinoblastoma protein-binding motif (LXCXE/D) in the majority of the Nsp15 of the severe acute respiratory syndrome coronavirus (SARS-CoV) and its orthologs in the alpha an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Coronavirus Infections
Share to Cricetinae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoribonucleases

Share to Murine hepatitis virus

Share to Protein Interaction Domains and Motifs

Share to Retinoblastoma Protein

Share to Viral Nonstructural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22301153
DOI: 10.1128/JVI.07012-11
PMCID: PMC3318636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22301153-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The coronavirus endoribonuclease Nsp15 interacts with retinoblastoma tumor suppressor protein.PMID 22301153Read ↗

Coronavirus endoribonuclease antagonizes ZBP1-mediated necroptosis and delays multiple cell death pathwaysSemantic proximity Read ↗

SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signalingSemantic proximity Read ↗

Structural and Biochemical Characterization of Endoribonuclease Nsp15 Encoded by Middle East Respiratory Syndrome CoronavirusSemantic proximity Read ↗

SARS-CoV-2 Nsp15 endoribonuclease subverts host defenses to enhance viral fitness in lung cellsSemantic proximity Read ↗

The Role of Coronavirus RNA-Processing Enzymes in Innate Immune EvasionSemantic proximity Read ↗

Recent insights into the structure and function of coronavirus ribonucleases.Semantic proximity Read ↗

The coronavirus nsp15 endoribonuclease: A puzzling protein and pertinent antiviral drug targetSemantic proximity Read ↗

SARS-CoV-2 Nsp15 Suppresses Type I Interferon Production by Inhibiting IRF3 Phosphorylation And Nuclear TranslocationSemantic proximity Read ↗

Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase.Semantic proximity Read ↗

SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7Semantic proximity Read ↗

SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responsesSemantic proximity Read ↗

In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated ProteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.