Impact of IL28B gene polymorphisms on interferon-λ3 plasma levels during pegylated interferon-α/ribavirin therapy for chronic hepatitis C in patients coinfected with HIV.

doi:10.1093/jac/dkr598

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Impact of IL28B gene polymorphisms on interferon-λ3 plasma levels during pegylated interferon-α/ribavirin therapy for chronic hepatitis C in patients coinfected with HIV.

The Journal of antimicrobial chemotherapy - 1 May 2012

Rallón Norma I, Soriano Vincent, Naggie Susanna, Restrepo Clara, McHutchison John, Vispo Eugenia, Benito José M

Abstract excerpt

OBJECTIVES: The mechanism explaining the strong association between IL28B rs12979860 polymorphisms and treatment outcome in chronic hepatitis C remains unclear. We explore whether IL28B protein [interferon (IFN)-λ3] plasma levels may vary according to IL28B genotype and/or following pegylated IFN-α/ribavirin therapy. PATIENTS AND METHODS: A total of 112 HIV/hepatitis C virus (HCV)-coinfected patients who...

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PMID: 22294646
DOI: 10.1093/jac/dkr598
PMCID: PMC3695611

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