Association between genetic variants in the tumour necrosis factor/lymphotoxin α/lymphotoxin β locus and primary Sjogren's syndrome in Scandinavian samples.

doi:10.1136/annrheumdis-2011-200446

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Article

Association between genetic variants in the tumour necrosis factor/lymphotoxin α/lymphotoxin β locus and primary Sjogren's syndrome in Scandinavian samples.

Annals of the rheumatic diseases - 1 Jun 2012

Bolstad Anne Isine, Le Hellard Stephanie, Kristjansdottir Gudlaug, Vasaitis Lilian, Kvarnström Marika, Sjöwall Christopher, Johnsen Svein Joar Auglænd, Eriksson Per, Omdal Roald, Brun Johan G, Wahren-Herlenius Marie, Theander Elke, Syvänen Ann-Christine, Rönnblom Lars, Nordmark Gunnel, Jonsson Roland

Abstract excerpt

OBJECTIVES: Lymphotoxin β (LTB) has been found to be upregulated in salivary glands of patients with primary Sjögren's syndrome (pSS). An animal model of pSS also showed ablation of the lymphoid organisation and a marked improvement in salivary gland function on blocking the LTB receptor pathway. This study aimed to investigate whether single-nucleotide polymorphisms (SNP) in the lymphotoxin α (LTA)/LTB/tumour...

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PMID: 22294627
DOI: 10.1136/annrheumdis-2011-200446

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