Article
NCR3/NKp30 contributes to pathogenesis in primary Sjogren's syndrome.
Science translational medicine - 24 Jul 2013
Rusakiewicz Sylvie, Nocturne Gaetane, Lazure Thierry, Semeraro Michaela, Flament Caroline, Caillat-Zucman Sophie, Sène Damien, Delahaye Nicolas, Vivier Eric, Chaba Kariman, Poirier-Colame Vichnou, Nordmark Gunnel, Eloranta Maija-Leena, Eriksson Per, Theander Elke, Forsblad-d'Elia Helena, Omdal Roald, Wahren-Herlenius Marie, Jonsson Roland, Rönnblom Lars, Nititham Joanne, Taylor Kimberly E, Lessard Christopher J, Sivils Kathy L Moser, Gottenberg Jacques-Eric, Criswell Lindsey A, Miceli-Richard Corinne, Zitvogel Laurence, Mariette Xavier
Abstract excerpt
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease characterized by a lymphocytic exocrinopathy. However, patients often have evidence of systemic autoimmunity, and they are at markedly increased risk for the development of non- Hodgkin's lymphoma. Similar to other autoimmune disorders, a strong interferon (IFN) signature is present among subsets of pSS patients, although the precise etiology...
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