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Sequence variation analysis of the E2 gene of human papilloma virus type 16 in cervical lesions from women in Greece.

Archives of virology - 1 May 2012

Tsakogiannis D, Ruether I G A, Kyriakopoulou Z, Pliaka V, Theoharopoulou A, Skordas V, Panotopoulou E, Nepka C, Markoulatos P

Abstract excerpt

The E2 gene of human papilloma virus is expressed at the early stage of the viral life cycle, encoding the E2 transcription factor, and regulates the expression of E6 and E7 oncogenes. Disruption of E2 gene due to viral integration inhibits the transcriptional suppression of the HPV oncogenes, inducing cell proliferation. In the present study, a total of 22 HPV16-positive cytological specimens derived from high-...

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PMID: 22294445
DOI: 10.1007/s00705-012-1236-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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