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Disruption Events in the HPV18 E1 and E2 Genes in Precancerous Cervical Lesions

20 Jul 2025

Abstract excerpt

Human papillomavirus 18 (HPV18) is the second most oncogenic high-risk HPV genotype, after HPV16, and is responsible for about 15% of cervical cancer cases worldwide. The integration of high-risk HPV DNA into the host genome leads to the disruption of the E1 and/or E2 genes, which is considered a risk factor for viral-induced carcinogenesis. This study examined the disruption events of HPV18 E1 and E2 genes in...

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PMID: 40725221
DOI: 10.3390/ijms26146974

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