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Asian-American variants of human papillomavirus type 16 have extensive mutations in theE2 gene and are highly amplified in cervical carcinomas

12 Nov 1999

Abstract excerpt

Human-papillomavirus (HPV)-E2 protein is involved in gene-expression regulation and replication of HPV genome. Disruption of the E2 gene during viral integration has been proposed as a mechanism of tumoral progression, since the expression of E6/E7 viral oncogenes is allowed. However, retention of E1/E2 genes and high viral amplification are frequently found in HPV16-positive carcinomas of some populations. In...

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PMID: 10508478
DOI: 10.1002/(sici)1097-0215(19991112)83:4<449::aid-ijc3>3.0.co;2-0

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Asian-American variants of human papillomavirus type 16 have extensive mutations in theE2 gene and are highly amplified in cervical carcinomasPMID 10508478Read ↗

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