Article
Molecular variants of human papilloma virus 16 E2, E4, E5, E6 and E7 genes associated with cervical neoplasia in Romanian patients.
Archives of virology - 1 Dec 2014
Plesa Adriana, Anton Gabriela, Iancu Iulia V, Diaconu Carmen C, Huica Irina, Stanescu Anca D, Socolov Demetra, Nistor Elena, Popa Elena, Stoian Mihai, Botezatu Anca
Abstract excerpt
The aim of this study was to identify and associate the sequence variations of human Papillomavirus 16 (HPV16) genes from women who live in two different areas of Romania and associate them with malignant progression. One hundred twenty-four HPV16-positive cervical isolates were collected, and the E2, E4, E5, E6 and E7 viral genes were sequenced. Two new missense mutations in the E6 gene (C279G and A305C) were...
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