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Article

Molecular and phylogenetic analysis of the HPV 16 E4 gene in cervical lesions from women in Greece.

Archives of virology - 1 Sept 2012

Tsakogiannis D, Ruether I G A, Kyriakopoulou Z, Pliaka V, Skordas V, Gartzonika C, Levidiotou-Stefanou S, Markoulatos P

Abstract excerpt

The HPV16 E1(∧)E4 protein is thought to contribute to the release of newly formed viral particles from infected epithelia. In order to investigate amino acid mutations in the HPV16 E1(∧)E4 protein, the complete E4 ORF was amplified by PCR in 27 HPV16-positive cervical samples, and the amplicons were cloned. Fifteen nucleic acid variations were identified in the E4 ORF, including seven silent nucleic acid...

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PMID: 22684534
DOI: 10.1007/s00705-012-1356-1

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