Article
A Proteogenomic Analysis of Haptoglobin in Malaria.
Proteomics. Clinical applications - 1 Jul 2018
Awasthi Gauri, Tyagi Suchi, Kumar Vipin, Patel Sandip Kumar, Rojh Dharmendar, Sakrappanavar Vijeth, Kochar Sanjay Kumar, Talukdar Arunansu, Samanta Biaus, Das Aparup, Srivastava Sanjeeva, Patankar Swati
Abstract excerpt
SCOPE: Haptoglobin (Hp), an acute phase inflammatory protein is associated with malaria pathogenesis in several proteomics and genomics studies. The Hp gene has two co-dominant alleles: Hp1 and Hp2 that produce three genotypes: Hp1/Hp1, Hp1/Hp2 and Hp2/Hp2. EXPERIMENTAL DESIGN: In this study, validation of the proteomics data with Multiple Reaction Monitoring Mass Spectroscopy (MRM-MS) is performed and the...
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