Article
Mitochondrial sorting and assembly machinery subunit Sam37 in Candida albicans: insight into the roles of mitochondria in fitness, cell wall integrity, and virulence.
Eukaryotic cell - 1 Apr 2012
Qu Yue, Jelicic Branka, Pettolino Filomena, Perry Andrew, Lo Tricia L, Hewitt Victoria L, Bantun Farkad, Beilharz Traude H, Peleg Anton Y, Lithgow Trevor, Djordjevic Julianne T, Traven Ana
Abstract excerpt
Recent studies indicate that mitochondrial functions impinge on cell wall integrity, drug tolerance, and virulence of human fungal pathogens. However, the mechanistic aspects of these processes are poorly understood. We focused on the mitochondrial outer membrane SAM (Sorting and Assembly Machinery) complex subunit Sam37 in Candida albicans. Inactivation of SAM37 in C. albicans leads to a large reduction in...
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