Article
Cell wall integrity is linked to mitochondria and phospholipid homeostasis in Candida albicans through the activity of the post-transcriptional regulator Ccr4-Pop2.
Molecular microbiology - 1 Feb 2011
Dagley Michael J, Gentle Ian E, Beilharz Traude H, Pettolino Filomena A, Djordjevic Julianne T, Lo Tricia L, Uwamahoro Nathalie, Rupasinghe Thusitha, Tull Dedreja L, McConville Malcolm, Beaurepaire Cecile, Nantel André, Lithgow Trevor, Mitchell Aaron P, Traven Ana
Abstract excerpt
The cell wall is essential for viability of fungi and is an effective drug target in pathogens such as Candida albicans. The contribution of post-transcriptional gene regulators to cell wall integrity in C. albicans is unknown. We show that the C. albicans Ccr4-Pop2 mRNA deadenylase, a regulator of mRNA stability and translation, is required for cell wall integrity. The ccr4/pop2 mutants display reduced wall...
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