Article
CCDC-55 is required for larval development and distal tip cell migration in Caenorhabditis elegans.
Mechanisms of development - 1 Jan 2000
Kovacevic Ismar, Ho Richard, Cram Erin J
Abstract excerpt
The Caenorhabditis elegans distal tip cells (DTCs) are an in vivo model for the study of developmentally regulated cell migration. In this study, we characterize a novel role for CCDC-55, a conserved coiled-coil domain containing protein, in DTC migration and larval development in C. elegans. Although animals homozygous for a probable null allele, ccdc-55(ok2851), display an early larval arrest, RNAi depletion...
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