Article
SDN-1/syndecan regulates growth factor signaling in distal tip cell migrations in C. elegans.
Developmental biology - 1 Oct 2009
Schwabiuk Megan, Coudiere Ludivine, Merz David C
Abstract excerpt
Mutations in the sdn-1/syndecan gene act as genetic enhancers of the ventral-to-dorsal distal tip cell (DTC) migration defects caused by a weak allele of the netrin receptor gene unc-5. The sdn-1(ev697) allele was identified in a genetic screen for enhancers of unc-5 DTC migration defects, and carried a nonsense mutation predicted to truncate the SDN-1 protein prior to the transmembrane domain. The enhancement of...
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