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Article

Repeatability and contingency in the evolution of a key innovation in phage lambda.

Science (New York, N.Y.) - 27 Jan 2012

Meyer Justin R, Dobias Devin T, Weitz Joshua S, Barrick Jeffrey E, Quick Ryan T, Lenski Richard E

Abstract excerpt

The processes responsible for the evolution of key innovations, whereby lineages acquire qualitatively new functions that expand their ecological opportunities, remain poorly understood. We examined how a virus, bacteriophage λ, evolved to infect its host, Escherichia coli, through a novel pathway. Natural selection promoted the fixation of mutations in the virus's host-recognition protein, J, that improved...

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Share to Bacterial Outer Membrane Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22282803
DOI: 10.1126/science.1214449
PMCID: PMC3306806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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