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Article

Bacteriophage lambda overcomes a perturbation in its host-viral genetic network through mutualism and evolution of life history traits.

Evolution; international journal of organic evolution - 1 Apr 2020

Gupta Animesh, Soto Anechelle N, Medina Sarah J, Petrie Katherine L, Meyer Justin R

Abstract excerpt

An important driver of evolution in viruses is natural selection to optimize the use of their hosts' genetic network. To learn how viruses respond to this pressure, we disrupted the genetic network of Escherichia coli to inhibit replication of its virus, bacteriophage lambda, and then observed how λ evolved to compensate. We deleted E. coli's dnaJ gene, which lambda uses to initiate DNA replication. Lambda...

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PMID: 31891185
DOI: 10.1111/evo.13920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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