Balance between promiscuity and specificity in phage λ host range.

Abstract excerpt

As hosts acquire resistance to viruses, viruses must overcome that resistance to re-establish infectivity, or go extinct. Despite the significant hurdles associated with adapting to a resistant host, viruses are evolutionarily successful and maintain stable coevolutionary relationships with their hosts. To investigate the factors underlying how pathogens adapt to their hosts, we performed a deep mutational scan...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bacteriophage lambda
• Share to Biological Evolution
• Share to Escherichia coli