Article
Destabilizing mutations encode nongenetic variation that drives evolutionary innovation.
Science (New York, N.Y.) - 30 Mar 2018
Petrie Katherine L, Palmer Nathan D, Johnson Daniel T, Medina Sarah J, Yan Stephanie J, Li Victor, Burmeister Alita R, Meyer Justin R
Abstract excerpt
Evolutionary innovations are often achieved by repurposing existing genes to perform new functions; however, the mechanisms enabling the transition from old to new remain controversial. We identified mutations in bacteriophage λ's host-recognition gene J that confer enhanced adsorption to λ's native receptor, LamB, and the ability to access a new receptor, OmpF. The mutations destabilize λ particles and cause...
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