Article
Prevalence of fluoroquinolone resistance among tuberculosis patients in Shanghai, China.
Antimicrobial agents and chemotherapy - 1 Jul 2009
Xu Peng, Li Xia, Zhao Ming, Gui Xiaohong, DeRiemer Kathryn, Gagneux Sebastien, Mei Jian, Gao Qian
Abstract excerpt
We determined the prevalence of fluoroquinolone resistance among the isolates of Mycobacterium tuberculosis from 605 pulmonary tuberculosis patients in Shanghai, China. Mutations in gyrA were found in 81.5% of phenotypically fluoroquinolone-resistant isolates and were used as a molecular marker of fluoroquinolone resistance. gyrA mutations were detected in 1.9% of strains pan-susceptible to first-line drugs and...
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