Article

VGLL3-centered network connects placental, vascular, and immune defects in preeclampsia

2025-06-03

Abstract excerpt

<h4>SUMMARY</h4> Preeclampsia affects approximately 1 in 10 pregnancies, leading to severe complications and long-term health risks for both mother and offspring. While the etiology remains unclear, preeclampsia has been linked to both autoimmunity and the timing of menarche. Through human single-cell and spatial analyses, coupled with in vitro, in vivo, and ex vivo models, we demonstrate that VGLL3, a transcript...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f23e432f-cd5f-5e91-b380-506eb14fe59c
DOI: 10.1101/2025.05.30.657097

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

VGLL3-centered network connects placental, vascular, and immune defects in preeclampsiaDOI 10.1101/2025.05.30.657097Read

Genomic Insights at the Maternal-Fetal Interface: Preeclampsia Subtypes and Clinical Implications.Semantic proximity Read

Placental whole transcriptome expression profile in patients with early-onset, late-onset preeclampsia and gestational diabetes mellitusSemantic proximity Read

Human Placenta and Evolving Insights into Pathological Changes of Preeclampsia: A Comprehensive Review of the Last DecadeSemantic proximity Read

An updated view on the origin and use of angiogenic biomarkers for preeclampsiaSemantic proximity Read

Translational Analysis of Mouse and Human Placental Protein and mRNA Reveals Distinct Molecular Pathologies in Human PreeclampsiaSemantic proximity Read

Two distinct molecular faces of preeclampsia revealed by single-cell transcriptomicsSemantic proximity Read

Placental Origins of Preeclampsia: Insights from Multi-Omic StudiesSemantic proximity Read

Placenta-Specific Genes, Their Regulation During Villous Trophoblast Differentiation and Dysregulation in Preterm PreeclampsiaSemantic proximity Read

Single-cell RNA-seq reveals developmental deficiencies in both the placentation and the decidualization in women with late-onset preeclampsiaSemantic proximity Read

Single-cell mapping of maternal–fetal cross-talk in preeclampsiaSemantic proximity Read

A cross-sectional analysis of syncytiotrophoblast membrane extracellular vesicles–derived transcriptomic biomarkers in early-onset preeclampsiaSemantic proximity Read

Overview of extracellular vesicles in the pathogenesis of preeclampsiaSemantic proximity Read