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CYP1B1 genotype and risk of cardiovascular disease, pulmonary disease, and cancer in 50,000 individuals.

Pharmacogenetics and genomics - 1 Sept 2009

Kaur-Knudsen Diljit, Nordestgaard Børge G, Tybjaerg-Hansen Anne, Bojesen Stig E

Abstract excerpt

OBJECTIVE: Cytochrome P450 (CYP) 1B1 enzymes metabolize tobacco-smoke polycyclic aromatic hydrocarbons and 17beta-estradiol. CYP1B1*3 (rs1056836 = Leu432Val = 4326C>G) and CYP1B1*4 (rs1800440 = Asn453Ser = 4390A>G) influence this metabolism. We, therefore, hypothesized that these two polymorphisms associate with risk of myocardial infarction (MI), ischemic heart disease (IHD), ischemic cerebrovascular disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19730035
DOI: 10.1097/FPC.0b013e32833042cb

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