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Article

Heme oxygenase-1 promoter polymorphism is associated with risk of malignant mesothelioma.

Lung - 1 Jun 2012

Murakami Aki, Fujimori Yoshihiro, Yoshikawa Yoshie, Yamada Shusai, Tamura Kunihiro, Hirayama Noriko, Terada Takayuki, Kuribayashi Kozo, Tabata Chiharu, Fukuoka Kazuya, Tamaoki Tomoko, Nakano Takashi

Abstract excerpt

BACKGROUND: Malignant mesothelioma is an aggressive tumor of serosal surfaces that is closely associated with asbestos exposure which induces oxidative stress. Heme oxygenase (HO)-1, a rate-limiting enzyme of heme degradation, plays a protective role against oxidative stress. The HO-1 gene promoter carries (GT)n repeats whose number is inversely related to transcriptional activity of the HO-1 gene. METHODS: To...

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Identifiers

PMID: 22271370
DOI: 10.1007/s00408-012-9371-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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