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Article

Impact of hypoxia on the double-strand break repair after photon and carbon ion irradiation of radioresistant HNSCC cells.

Scientific reports - 7 Dec 2020

Wozny Anne-Sophie, Alphonse Gersende, Cassard Audrey, Malésys Céline, Louati Safa, Beuve Michael, Lalle Philippe, Ardail Dominique, Nakajima Tetsuo, Rodriguez-Lafrasse Claire

Abstract excerpt

DNA double-strand breaks (DSBs) induced by photon irradiation are the most deleterious damage for cancer cells and their efficient repair may contribute to radioresistance, particularly in hypoxic conditions. Carbon ions (C-ions) act independently of the oxygen concentration and trigger complex- and clustered-DSBs difficult to repair. Understanding the interrelation between hypoxia, radiation-type, and DNA-repair...

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Identifiers

PMID: 33288855
DOI: 10.1038/s41598-020-78354-7
PMCID: PMC7721800

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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