Article
Genetic variation at CR1 increases risk of cerebral amyloid angiopathy.
Neurology - 31 Jan 2012
Biffi A, Shulman J M, Jagiella J M, Cortellini L, Ayres A M, Schwab K, Brown D L, Silliman S L, Selim M, Worrall B B, Meschia J F, Slowik A, De Jager P L, Greenberg S M, Schneider J A, Bennett D A, Rosand J
Abstract excerpt
OBJECTIVE: Accumulated evidence suggests that a variant within the CR1 gene (single nucleotide polymorphism rs6656401), known to increase risk for Alzheimer disease (AD), influences β-amyloid (Aβ) deposition in brain tissue. Given the biologic overlap between AD and cerebral amyloid angiopathy (CAA), a leading cause of intracerebral hemorrhage (ICH) in elderly individuals, we investigated whether rs6656401...
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