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Article

STAT1 inhibits human hepatocellular carcinoma cell growth through induction of p53 and Fbxw7

26 Nov 2015

Abstract excerpt

BACKGROUND: Aberrant STAT1 signaling is observed in human hepatocellular carcinoma (HCC) and has been associated with the modulation of cell proliferation and survival. However, the role of STAT1 signaling in HCC and its underlying mechanism remain elusive. METHODS: We transiently transfected pcDNA3.1-STAT1 and STAT1 siRNA into SMMC7721 and HepG2 cells. Western blot and qRT-PCR examined the expression of protein...

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PMID: 26617467
DOI: 10.1186/s12935-015-0253-6

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