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Article

Resistance to Systemic Therapies in Clear Cell Renal Cell Carcinoma: Mechanisms and Management Strategies.

Molecular cancer therapeutics - 1 Jul 2018

Makhov Peter, Joshi Shreyas, Ghatalia Pooja, Kutikov Alexander, Uzzo Robert G, Kolenko Vladimir M

Abstract excerpt

Renal cell carcinoma (RCC) is the most common form of kidney cancer. It is categorized into various subtypes, with clear cell RCC (ccRCC) representing about 85% of all RCC tumors. The lack of sensitivity to chemotherapy and radiation therapy prompted research efforts into novel treatment options. The development of targeted therapeutics, including multi-targeted tyrosine kinase inhibitors (TKI) and mTOR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29967214
DOI: 10.1158/1535-7163.MCT-17-1299
PMCID: PMC6034114

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