Article
Discovery of novel variants in genotyping arrays improves genotype retention and reduces ascertainment bias.
BMC genomics - 19 Jan 2012
Didion John P, Yang Hyuna, Sheppard Keith, Fu Chen-Ping, McMillan Leonard, de Villena Fernando Pardo-Manuel, Churchill Gary A
Abstract excerpt
BACKGROUND: High-density genotyping arrays that measure hybridization of genomic DNA fragments to allele-specific oligonucleotide probes are widely used to genotype single nucleotide polymorphisms (SNPs) in genetic studies, including human genome-wide association studies. Hybridization intensities are converted to genotype calls by clustering algorithms that assign each sample to a genotype class at each SNP....
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