Proteasomal insensitivity of apoptin in tumor cells.

doi:10.1016/j.bbrc.2012.04.132

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Article

Proteasomal insensitivity of apoptin in tumor cells.

Biochemical and biophysical research communications - 25 May 2012

Lanz Henriëtte L, Suijker Johnny, Noteborn Mathieu H M, Backendorf Claude

Abstract excerpt

The small viral protein apoptin is capable of inducing apoptosis selectively in human tumor cells. In normal cells apoptin localizes in the cytoplasm where it forms aggregates, becomes epitope-shielded and eventually degraded. By inhibiting the proteasome activity with the chemical inhibitors bortezomib and Ada-Ahx(3)L(3)VS apoptin levels can be stabilized in normal cells similar to the tumor suppressor p53...

Topics

Antineoplastic Agents
Boronic Acids
Bortezomib
Capsid Proteins
Cell Line
Cell Line, Tumor
Fibroblasts
Humans
Mutation
Neoplasms
Phosphorylation
Proteasome Endopeptidase Complex
Protein Stability
Proteolysis
Pyrazines
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 22575449
DOI: 10.1016/j.bbrc.2012.04.132

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