Autophagy and cancer

doi:10.3858/emm.2012.44.2.033

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Autophagy and cancer

1 Jan 2012

Abstract excerpt

Basal autophagy plays a critical role in maintaining cellular homeostasis and genomic integrity by degrading aged or malfunctioning organelles and damaged or misfolded proteins. However, autophagy also plays a complicated role in tumorigenesis and treatment responsiveness. It can be tumor-suppressing during the early stages of tumorigenesis (i.e., it is an anti-tumor mechanism), as reduced autophagy is found in...

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PMID: 22257886
DOI: 10.3858/emm.2012.44.2.033

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