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Article

Autophagy and tumorigenesis

24 Dec 2009

Abstract excerpt

Autophagy, or cellular self-digestion, is activated in cancer cells in response to multiple stresses and has been demonstrated to promote tumor cell survival and drug resistance. Nonetheless, genetic evidence supports that autophagy functions as a tumor suppressor mechanism. Hence, the precise role of autophagy during cancer progression and treatment is both tissue and context dependent. Here, we discuss our...

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PMID: 20035753
DOI: 10.1016/j.febslet.2009.12.034

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