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Article

Curing of plasmid pXO1 from Bacillus anthracis using plasmid incompatibility.

PloS one - 1 Jan 2012

Liu Xiankai, Wang Dongshu, Wang Huagui, Feng Erling, Zhu Li, Wang Hengliang

Abstract excerpt

The large plasmid pXO1 encoding the anthrax toxin is important for the virulence of Bacillus anthracis. It is essential to cure pXO1 from B. anthracis to evaluate its role in the pathogenesis of anthrax infection. Because conventional methods for curing plasmids (e.g., curing agents or growth at elevated temperatures) can induce mutations in the host chromosomal DNA, we developed a specific and reliable method to...

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Identifiers

PMID: 22253811
DOI: 10.1371/journal.pone.0029875
PMCID: PMC3256208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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