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Article

Mitochondrial electron transport is the cellular target of the oncology drug elesclomol.

PloS one - 1 Jan 2012

Blackman Ronald K, Cheung-Ong Kahlin, Gebbia Marinella, Proia David A, He Suqin, Kepros Jane, Jonneaux Aurelie, Marchetti Philippe, Kluza Jerome, Rao Patricia E, Wada Yumiko, Giaever Guri, Nislow Corey

Abstract excerpt

Elesclomol is a first-in-class investigational drug currently undergoing clinical evaluation as a novel cancer therapeutic. The potent antitumor activity of the compound results from the elevation of reactive oxygen species (ROS) and oxidative stress to levels incompatible with cellular survival. However, the molecular target(s) and mechanism by which elesclomol generates ROS and subsequent cell death were...

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Identifiers

PMID: 22253786
DOI: 10.1371/journal.pone.0029798
PMCID: PMC3256171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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