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Article

Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma.

Nature communications - 6 Mar 2020

Bajpai Richa, Sharma Aditi, Achreja Abhinav, Edgar Claudia L, Wei Changyong, Siddiqa Arusha A, Gupta Vikas A, Matulis Shannon M, McBrayer Samuel K, Mittal Anjali, Rupji Manali, Barwick Benjamin G, Lonial Sagar, Nooka Ajay K, Boise Lawrence H, Nagrath Deepak, Shanmugam Mala

Abstract excerpt

The BCL-2 antagonist venetoclax is highly effective in multiple myeloma (MM) patients exhibiting the 11;14 translocation, the mechanistic basis of which is unknown. In evaluating cellular energetics and metabolism of t(11;14) and non-t(11;14) MM, we determine that venetoclax-sensitive myeloma has reduced mitochondrial respiration. Consistent with this, low electron transport chain (ETC) Complex I and Complex II...

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Share to Bridged Bicyclo Compounds, Heterocyclic
Share to Chromosomes, Human, Pair 14

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Electron Transport Complex I

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Share to Multiple Myeloma

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Share to Proto-Oncogene Proteins c-bcl-2

Source

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Identifiers

PMID: 32144272
DOI: 10.1038/s41467-020-15051-z
PMCID: PMC7060223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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