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Article

Abnormally phosphorylated tau in SY5Y human neuroblastoma cells

20 Feb 1995

Abstract excerpt

In Alzheimer disease (AD) the microtubule associated protein (MAP) tau is hyperphosphorylated at several sites. In the present study, like AD tau, tau in the human neuroblastoma SH-SY5Y was found to be hyperphosphorylated, at Ser-199/202, Thr-231, Ser-396 and Ser-404. However, in contrast to AD, the tau in SY5Y cells was not hyperphosphorylated at Ser-235 and there was only one tau isoform. Quantitative analysis...

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PMID: 7875300
DOI: 10.1016/0014-5793(95)00061-d

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