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Article

Somatic mutations affecting the selectivity filter of KCNJ5 are frequent in 2 large unselected collections of adrenal aldosteronomas.

Hypertension (Dallas, Tex. : 1979) - 1 Mar 2012

Azizan Elena A B, Murthy Meena, Stowasser Michael, Gordon Richard, Kowalski Bartosz, Xu Shengxin, Brown Morris J, O'Shaughnessy Kevin M

Abstract excerpt

Primary hyperaldosteronism, one cause of which is aldosterone-producing adenomas (APAs), may account for ≤5% to 10% of cases of essential hypertension. Germline mutations have been identified in 2 rare familial forms of primary hyperaldosteronism, but it has been reported recently that somatic mutations of the KCNJ5 gene, which encodes a potassium channel, are present in some sporadic nonsyndromic APAs. To...

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Source

Identifiers

PMID: 22252394
DOI: 10.1161/HYPERTENSIONAHA.111.186239

Genes

KCNJ5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic mutations affecting the selectivity filter of KCNJ5 are frequent in 2 large unselected collections of adrenal aldosteronomas.PMID 22252394Read ↗

Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter.Semantic proximity Read ↗

Novel Insertion Mutation in KCNJ5 Channel Produces Constitutive Aldosterone Release From H295R Cells.Semantic proximity Read ↗

A Novel KCNJ5-insT149 Somatic Mutation Close to, but Outside, the Selectivity Filter Causes Resistant Hypertension by Loss of Selectivity for PotassiumSemantic proximity Read ↗

K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension.Semantic proximity Read ↗

New insights into aldosterone-producing adenomas and hereditary aldosteronism: mutations in the K+ channel KCNJ5.Semantic proximity Read ↗

Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism.Semantic proximity Read ↗

A Meta-Analysis of Somatic KCNJ5 K(+) Channel Mutations In 1636 Patients With an Aldosterone-Producing Adenoma.Semantic proximity Read ↗

Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma.Semantic proximity Read ↗

Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5.Semantic proximity Read ↗

Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype.Semantic proximity Read ↗

Role for germline mutations and a rare coding single nucleotide polymorphism within the KCNJ5 potassium channel in a large cohort of sporadic cases of primary aldosteronism.Semantic proximity Read ↗

Clinical Translationality of KCNJ5 Mutation in Aldosterone Producing Adenoma.Semantic proximity Read ↗

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