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Article

Contribution of the OBSCN nonsynonymous variants to aspirin exacerbated respiratory disease susceptibility in Korean population.

DNA and cell biology - 1 Jun 2012

Kim Jeong-Hyun, Park Byung-Lae, Pasaje Charisse Flerida A, Kim Yongha, Bae Joon Seol, Park Jong Sook, Uh Soo-Taek, Kim Yong-Hoon, Kim Mi-Kyeong, Choi Inseon S, Cho Sang Heon, Choi Byoung Whui, Koh InSong, Park Choon-Sik, Shin Hyoung Doo

Abstract excerpt

Airway remodeling and exacerbated airway narrowing in asthma have been attributed to the regulation of intracellular Ca(2+) by sarcoplasmic reticulum (SR) of the airway smooth muscle cells. The protein encoded by obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (OBSCN) is a crucial factor in determining the SR architecture in Obscn(-/-) mice. This study genotyped a total of 55 common...

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Identifiers

PMID: 22251166
DOI: 10.1089/dna.2011.1436
PMCID: PMC3378958

Genes

OBSCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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