Association of systemic lupus erythematosus with decreased immunosuppressive potential of the IgG glycome.

doi:10.1002/art.39273

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Article

Association of systemic lupus erythematosus with decreased immunosuppressive potential of the IgG glycome.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Nov 2015

Vučković Frano, Krištić Jasminka, Gudelj Ivan, Teruel Maria, Keser Toma, Pezer Marija, Pučić-Baković Maja, Štambuk Jerko, Trbojević-Akmačić Irena, Barrios Clara, Pavić Tamara, Menni Cristina, Wang Youxin, Zhou Yong, Cui Liufu, Song Haicheng, Zeng Qiang, Guo Xiuhua, Pons-Estel Bernardo A, McKeigue Paul, Leslie Patrick Alan, Gornik Olga, Spector Tim D, Harjaček Miroslav, Alarcon-Riquelme Marta, Molokhia Mariam, Wang Wei, Lauc Gordan

Abstract excerpt

OBJECTIVE: Glycans attached to the Fc portion of IgG are important modulators of IgG effector functions. Interindividual differences in IgG glycome composition are large and they associate strongly with different inflammatory and autoimmune diseases. IKZF1, HLA-DQ2A/B, and BACH2 genetic loci that affect IgG glycome composition show pleiotropy with systemic lupus erythematosus (SLE), indicating a potentially...

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Identifiers

PMID: 26200652
DOI: 10.1002/art.39273
PMCID: PMC4626261

Genes

BACH2
IKZF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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