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EBV lytic infection enhances transformation of B‐lymphocytes infected with EBV in the presence of T‐lymphocytes

13 Jan 2012

Abstract excerpt

Epstein-Barr virus (EBV) establishes lifelong latency in B-lymphocytes following infection. Although in immune-competent individuals EBV remains in a quiescent state, in immunodeficient individuals, such as those with AIDS or transplant recipients, B-lymphocytes infected with EBV proliferate to give rise to lymphoproliferative diseases. Similarly, in vitro, EBV transforms human B-lymphocytes into indefinitely...

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PMID: 22246839
DOI: 10.1002/jmv.23208

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