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Article

Conserved epitopes with high HLA-I population coverage are targets of CD8+ T cells associated with high IFN-γ responses against all dengue virus serotypes.

Scientific reports - 24 Nov 2020

Adikari Thiruni N, Di Giallonardo Francesca, Leung Preston, Grifoni Alba, Sette Alex, Weiskopf Daniela, Bull Rowena A, Luciani Fabio

Abstract excerpt

Cytotoxic CD8+ T cells are key for immune protection against viral infections. The breadth and cross-reactivity of these responses are important against rapidly mutating RNA viruses, such as dengue (DENV), yet how viral diversity affect T cell responses and their cross-reactivity against multiple variants of the virus remains poorly defined. In this study, an integrated analysis was performed to map...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33235334
DOI: 10.1038/s41598-020-77565-2
PMCID: PMC7687909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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