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Article

Stabilization of the predominant disease-causing aldolase variant (A149P) with zwitterionic osmolytes.

Biochemistry - 8 Feb 2011

Stopa Jack D, Chandani Sushil, Tolan Dean R

Abstract excerpt

Hereditary fructose intolerance (HFI) is a disease of carbohydrate metabolism that can result in hyperuricemia, hypoglycemia, liver and kidney failure, coma, and death. Currently, the only treatment for HFI is a strict fructose-free diet. HFI arises from aldolase B deficiency, and the most predominant HFI mutation is an alanine to proline substitution at position 149 (A149P). The resulting aldolase B with the...

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Identifiers

PMID: 21166391
DOI: 10.1021/bi101523x
PMCID: PMC3034293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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