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Article

Revisiting the contribution of negative charges on the chaperonin cage wall to the acceleration of protein folding.

Proceedings of the National Academy of Sciences of the United States of America - 25 Sept 2012

Motojima Fumihiro, Motojima-Miyazaki Yuko, Yoshida Masasuke

Abstract excerpt

Chaperonin GroEL mediates the folding of protein encapsulated in a GroES-sealed cavity (cage). Recently, a critical role of negative charge clusters on the cage wall in folding acceleration was proposed based on experiments using GroEL single-ring (SR) mutants SR1 and SRKKK2 [Tang YC, et al. (200...

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Identifiers

PMID: 22961256
DOI: 10.1073/pnas.1204547109
PMCID: PMC3465421

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-22961256-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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