Article
Human placental-specific epipolymorphism and its association with adverse pregnancy outcomes.
PloS one - 19 Oct 2009
Yuen Ryan K C, Avila Luana, Peñaherrera Maria S, von Dadelszen Peter, Lefebvre Louis, Kobor Michael S, Robinson Wendy P
Abstract excerpt
Interindividual variation in DNA-methylation level is widespread in the human genome, despite its critical role in regulating gene expression. The nature of this variation, including its tissue-specific nature, and the role it may play in human phenotypic variation and disease is still poorly characterized. The placenta plays a critical role in regulating fetal growth and development in ways that have lifelong...
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