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Article

Epigenetic regulation of maspin expression in the human placenta

26 Aug 2006

Abstract excerpt

Maspin, a tumour suppressor gene, is differentially expressed in the human placenta. Decreased expression of maspin in the first trimester corresponds with the period of maximum trophoblast invasion, suggesting a role in cell invasion and motility. Although methylation of CpG islands regulates maspin expression in cancer cells, the mechanism of maspin regulation in the human placenta is unknown. Our objectives...

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PMID: 16936308
DOI: 10.1093/molehr/gal074

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