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Article

Expressional and Epigenetic Alterations of Placental Serine Protease Inhibitors

7 Nov 2006

Abstract excerpt

Preeclampsia is the major pregnancy-induced hypertensive disorder. It modifies the expression profile of placental genes, including several serine protease inhibitors (SERPINs). The objective of this study was to perform a systematic expression analysis of these genes in normal and pathological placentas and to pinpoint epigenetic alterations inside their promoter regions. Expression of 18 placental SERPINs was...

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PMID: 17088445
DOI: 10.1161/01.hyp.0000250831.52876.cb

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